Pharmacist Formulated

Pharmacist Formulated

UnPhazed was created by licensed phamacists with a clinical background and a focus on building a formula that truly supports the body. Each ingredient was selected based on scientific evidence, known physiological mechanisms, and real-world symptom patterns — not trends or marketing claims.

UnPhazed is meant to give you a more complete approach, since it is designed to support multiple systems simultaneously, including hormone metabolism, neurotransmitter production, and neuromuscular relaxation. This multi-targeted approach reflects the complex physiology underlying PMS.

The Science Behind PMS: What is Actually Happening?

PMS isn’t caused by just one factor. These systems are interconnected — which is why PMS symptoms can feel both emotional and physical at the same time.

Hormonal Shifts

Fluctuations in estrogen and progesterone can influence receptor activity and signaling, contributing to symptoms such as mood changes and fluid retention.¹⁻³

Neurotransmitter Changes

Serotonin and dopamine activity can be affected across the cycle, influencing mood, irritability, and energy levels.¹⁻³

Physical Stress and Inflammation

Increased prostaglandin production and inflammatory mediators can contribute to cramping and discomfort.¹⁻³

Chasteberry (Vitex): Hormone Balance

Chasteberry (Vitex): Hormone Balance

Clinical studies suggest Vitex may support hormonal balance by influencing prolactin and luteal phase function.⁴,⁵ This supports progesterone and cycle regulation

Magnesium glycinate: Calms the body and mind

Magnesium glycinate: Calms the body and mind

Magnesium supports neuromuscular function and neurotransmitter activity, which reduces cramps, tension, and mood swings.⁶,⁷

Diindolylmethane: Supports Estrogen Metabolism

Diindolylmethane: Supports Estrogen Metabolism

DIM supports estrogen metabolism by promoting pathways associated with more favorable estrogen metabolites.⁸ This helps process and clear excess estrogen. DIM comes from cruciferous vegetables, such as broccoli and cauliflower.

Vitamin B6 as Pyridoxal 5′-Phosphate: Stabilizes Mood

Vitamin B6 as Pyridoxal 5′-Phosphate: Stabilizes Mood

Vitamin B6 in its bioavailable form, P5P, is a cofactor in neurotransmitter synthesis, such as serotonin and dopamine and has been shown to help reduce PMS-related mood symptoms.⁹

Why This Formula Works

Rather than focusing on a single symptom, Unphazed brings together ingredients that support hormonal balance, mood regulation, and physical comfort — providing a more comprehensive approach to cycle support.

Disclaimer

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References

1. Rapkin AJ, Winer SA. Premenstrual syndrome and premenstrual dysphoric disorder. J Clin Psychiatry. 2009;70(11):1539-1544.

2. Roca CA, Schmidt PJ, Rubinow DR. Differential menstrual cycle regulation of the hypothalamic-pituitary-adrenal axis. J Clin Endocrinol Metab. 2003;88(7):3057-3063.

3. Bertone-Johnson ER, et al. Calcium and vitamin D intake and risk of incident PMS. Arch Intern Med. 2005;165(11):1246-1252.

4. Wuttke W, Seidlová-Wuttke D, Gorkow C. Vitex agnus-castus: pharmacology and clinical applications. Phytomedicine. 2003;10(4):348-357.

5. Schellenberg R. Treatment for PMS with Vitex extract Ze 440. BMJ. 2001;322(7279):134-137.

6. Walker AF, et al. Magnesium supplementation alleviates PMS symptoms. J Womens Health. 1998;7(9):1157-1165.

7. De Souza MC, et al. Combined magnesium and vitamin B6 supplementation in PMS. Int J Gynaecol Obstet. 2000;71(3):293-298.

8. Reed GA, et al. Single-dose and multiple-dose administration of DIM. Cancer Epidemiol Biomarkers Prev. 2006;15(12):2477-2481.

9. Wyatt KM, et al. Efficacy of vitamin B6 in PMS treatment. BMJ. 1999;318(7195):1375-1381.